somatrogon   Click here for help

GtoPdb Ligand ID: 12013

Synonyms: hGH-CTP | MOD-4023 | MOD4023 | Ngenla® | somatrogon-ghla
Approved drug
somatrogon is an approved drug (EMA (2022), FDA (2023))
Comment: Somatrogon is a recombinant chimeric protein that contains the amino acid sequence of human growth hormone (hGH) and three copies of the 28 aa carboxy-terminal peptide (CTP) from human chorionic gonadotropin (CTP-hGH-CTP-CTP). It acts as a long-acting growth hormone replacement with pharmacokinetics that support once-weekly administration [2].
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Growth hormone receptor Rn Agonist Agonist 8.3 pKd - 2
pKd 8.3 (Kd 5.12x10-9 M) [2]
Growth hormone receptor Hs Agonist Agonist 8.2 pKd - 2
pKd 8.2 (Kd 6.38x10-9 M) [2]
Description: Binding affinity determined by SPR assay
Growth hormone receptor Monkey Agonist Agonist 7.9 pKd - 2
pKd 7.9 (Kd 1.146x10-8 M) [2]