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Growth hormone receptor

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Target not currently curated in GtoImmuPdb

Target id: 1720

Nomenclature: Growth hormone receptor

Family: Prolactin receptor family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 638 5p13.1-p12 GHR growth hormone receptor
Mouse 1 650 15 1.84 cM Ghr growth hormone receptor
Rat 1 638 2q16 Ghr growth hormone receptor
Previous and Unofficial Names Click here for help
GH-binding protein | GHBP | GH receptor | somatotropin receptor
Database Links Click here for help
Alphafold
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
Pharos
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Human growth hormone bound to the growth hormone receptor
PDB Id:  1A22
Ligand:  growth hormone 1
Resolution:  2.6Å
Species:  Human
References:  1
Natural/Endogenous Ligands Click here for help
growth hormone 1 {Sp: Human}
growth hormone 2 {Sp: Human}

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
growth hormone 1 {Sp: Human} Peptide Approved drug Primary target of this compound Ligand is endogenous in the given species Hs Agonist - -
growth hormone 2 {Sp: Human} Peptide Ligand is endogenous in the given species Hs Agonist - -
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
pegvisomant Peptide Approved drug Primary target of this compound Hs Antagonist - - 2
[2]
Immuno Process Associations
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0031623 receptor internalization IDA
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GO:0006897 endocytosis IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0004903 growth hormone receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0034097 response to cytokine IEP
GO:0070555 response to interleukin-1 IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Growth hormone insensitivity, partial; GHIP
Synonyms: Short stature due to partial GHR deficiency [Orphanet: ORPHA314802]
OMIM: 604271
Orphanet: ORPHA314802
Disease:  Hypercholesterolemia, familial
Disease Ontology: DOID:13810
OMIM: 143890
Disease:  Laron syndrome
Disease Ontology: DOID:9521
OMIM: 262500
Orphanet: ORPHA633

References

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1. Clackson T, Ultsch MH, Wells JA, de Vos AM. (1998) Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J Mol Biol, 277 (5): 1111-28. [PMID:9571026]

2. Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML et al.. (2000) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med, 342 (16): 1171-7. [PMID:10770982]

How to cite this page

Prolactin receptor family: Growth hormone receptor. Last modified on 23/01/2015. Accessed on 22/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1720.