Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	638	5p13.1-p12	GHR	growth hormone receptor
Mouse	1	650	15 1.84 cM	Ghr	growth hormone receptor
Rat	1	638	2q16	Ghr	growth hormone receptor

Previous and Unofficial Names

GH-binding protein | GHBP | GH receptor | somatotropin receptor

Database Links
Alphafold	P10912 (Hs), P16882 (Mm), P16310 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL1976 (Hs)
DrugBank Target	P10912 (Hs)
Ensembl Gene	ENSG00000112964 (Hs), ENSMUSG00000055737 (Mm), ENSRNOG00000015654 (Rn)
Entrez Gene	2690 (Hs), 14600 (Mm), 25235 (Rn)
Human Protein Atlas	ENSG00000112964 (Hs)
KEGG Gene	hsa:2690 (Hs), mmu:14600 (Mm), rno:25235 (Rn)
OMIM	600946 (Hs)
Orphanet	ORPHA122095 (Hs)
Pharos	P10912 (Hs)
UniProtKB	P10912 (Hs), P16882 (Mm), P16310 (Rn)
Wikipedia	GHR (Hs)

Selected 3D Structures
	Description:  Human growth hormone bound to the growth hormone receptor PDB Id:  1A22 Ligand:  growth hormone 1 Resolution:  2.6Å Species:  Human References:  1

Natural/Endogenous Ligands
growth hormone 1 {Sp: Human}
growth hormone 2 {Sp: Human}

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference growth hormone 1 {Sp: Human} Hs Agonist 9.0 pKd 2 ⤷ pKd 9.0 (Kd 9.1x10-10 M) [2] Description: Binding affinity of recombinant GH1 (somatropin), to immobilised hGHR by SPR somatrogon Rn Agonist 8.3 pKd 2 ⤷ pKd 8.3 (Kd 5.12x10-9 M) [2] somatrogon Hs Agonist 8.2 pKd 2 ⤷ pKd 8.2 (Kd 6.38x10-9 M) [2] Description: Binding affinity determined by SPR assay somatrogon Monkey Agonist 7.9 pKd 2 ⤷ pKd 7.9 (Kd 1.146x10-8 M) [2] growth hormone 2 {Sp: Human} Hs Agonist - - ⤷
View species-specific agonist tables

Antagonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference pegvisomant Hs Antagonist - - 3 ⤷ [3]

Immuno Process Associations

Immuno Process:  Antigen presentation

Immuno Process:  Cytokine production & signalling

Clinically-Relevant Mutations and Pathophysiology
Disease:  Growth hormone insensitivity, partial; GHIP Synonyms: Short stature due to partial GHR deficiency [Orphanet: ORPHA314802] OMIM: 604271 Orphanet: ORPHA314802
Disease:  Hypercholesterolemia, familial Disease Ontology: DOID:13810 OMIM: 143890
Disease:  Laron syndrome Disease Ontology: DOID:9521 OMIM: 262500 Orphanet: ORPHA633