Growth hormone receptor | Prolactin receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

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Growth hormone receptor

Target not currently curated in GtoImmuPdb

Target id: 1720

Nomenclature: Growth hormone receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 638 5p14-p12 GHR growth hormone receptor
Mouse 1 650 15 1.84 cM Ghr growth hormone receptor
Rat 1 638 2q16 Ghr growth hormone receptor
Previous and Unofficial Names
GH-binding protein | GHBP | GH receptor | somatotropin receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Human growth hormone bound to the growth hormone receptor
PDB Id:  1A22
Ligand:  growth hormone 1
Resolution:  2.6Å
Species:  Human
References:  1
Natural/Endogenous Ligands
growth hormone 1 {Sp: Human}
growth hormone 2 {Sp: Human}

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
growth hormone 1 {Sp: Human} Hs Agonist - -
growth hormone 2 {Sp: Human} Hs Agonist - -
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
pegvisomant Hs Antagonist - - 2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Growth hormone insensitivity, partial; GHIP
Synonyms: Short stature due to partial GHR deficiency [Orphanet: ORPHA314802]
OMIM: 604271
Orphanet: ORPHA314802
Disease:  Hypercholesterolemia, familial
Disease Ontology: DOID:13810
OMIM: 143890
Disease:  Laron syndrome
Disease Ontology: DOID:9521
OMIM: 262500
Orphanet: ORPHA633


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1. Clackson T, Ultsch MH, Wells JA, de Vos AM. (1998) Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J. Mol. Biol., 277 (5): 1111-28. [PMID:9571026]

2. Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML et al.. (2000) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N. Engl. J. Med., 342 (16): 1171-7. [PMID:10770982]

How to cite this page

Prolactin receptor family: Growth hormone receptor. Last modified on 23/01/2015. Accessed on 18/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY,