Compound class:
Synthetic organic
Comment: This compound is reported as a thyroid receptor β (THRβ)-selective agonist [1]. It activates the wild type receptor and the subfunctional mutant receptor THRβH435R which has impaired sensitivity to thyroid hormones and underlies resistance to thyroid hormone in carriers.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
16g activates THRβ with the H435R mutation with an EC50 of ~1300 nM [1]. It does not activate THRα, or inhibit a range of CYP450 enzymes and has no hERG affinity. |
Selectivity at nuclear hormone receptors | ||||||||||||||||||||||||||||||||||
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