Synonyms: ONO-7475 | ONO7475
Compound class:
Synthetic organic
Comment: We obtained the chemical structure for tamnorzatinib from the WHO's proposed INN list 127 (21 July 2022). In this document it was described as a tyrosine kinase inhibitor and antineoplastic. PubChem provided the synonym ONO-7475. ONO-7475 is a clinical stage inhibitor of the TAM family receptor tyrosine kinases AXL and MER, that has been developed as a drug for the treatment of leukaemia and advanced solid tumours [1,3].
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Bioactivity Comments |
Although there is evidence of the effect of tamnorzatinib (ONO-7475) on cancer cells lines and in xenograft models [1-3], we have been unable to find quantitative data for its inhibition potency at its proposed molecular targets. |