Synonyms: 3',4'-dideoxykanamycin B | debecacin
dibekacin is an approved drug
Compound class:
Synthetic organic
Comment: Dibekacin is a semisynthetic derivative of bekanamycin (kanamycin B), with activity against Gram-positive and Gram-negative bacteria [1]. It belongs to the aminoglycoside class of antibacterial compounds.
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Bioactivity Comments |
MIC for in vitro antibacterial activity against Staphylococcus aureus FDA 209P (0.78 μg/ml) and Escherichia coli (1.56 μg/ml) is similar to bekanamycin [1]. The same study found that dibekacin demonstrates activity against E. coli strains carrying the R factor (1.56-3.12 μg/ml) and against Pseudomonas aeruginosa (0.78-6.25 μg/ml), for which bekanamycin shows no activity. |