Synonyms: compound 4 [PMID: 32550990] [1] | TDRL551
Compound class:
Synthetic organic
Comment: TDRL-551 is a small molecule that was desigend by NERx BioSciences to block the interaction between replication protein A (RPA) and single stranded DNA, as a mechanism to enhance the efficacy of platinum-containing chemotherapy drugs [1].
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Bioactivity Comments |
TDRL-551 inhibits the RPA/DNA interaction with an IC50 of 15.3 μM in vitro [1]. |