Synonyms: ACP-044 | ACP044 | compound 1 [WO2020159643A1] [1]
Compound class:
Synthetic organic
Comment: The chemical structure for ebaresdax is claimed in Cersci Therapeutics' patent WO2020159643A1 [1], which allowed us to associate this structure with their clinical lead candidate ACP-044. This was confirmed by synonym matches on PubChem. Ebaresdax (ACP-044) is a first-in-class, orally administered, non-opioid analgesic that was developed for potential to treat neuropathic, surgical and osteoarthritic pain.
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Bioactivity Comments |
Ebaresdax is proposed to target nitro-oxidative stress in pain, by breaking down peroxynitrite (OONO, a reactive nitrogen species) that's produced as a by-product of tissue damage. Peroxynitrite causes changes in excitability in sensory afferent nerves, which manifests as the 'pain' sensation. |