[3H]pyrilamine   Click here for help

GtoPdb Ligand ID: 1220

Synonyms: [3H]mepyramine
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 28.6
Molecular weight 285.18
XLogP 3.19
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES COc1ccc(cc1)CN(c1ccccn1)CCN(C)C
Isomeric SMILES COc1ccc(cc1)CN(c1ccc(cn1)[3H])CCN(C)C
InChI InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3/i5T
InChI Key YECBIJXISLIIDS-XHHURNKPSA-N
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
H1 receptor Hs Antagonist Inverse agonist 8.4 – 9.1 pKd - 1-2,4-5
pKd 8.4 – 9.1 (Kd 4x10-9 – 7.9x10-10 M) [1-2,4-5]
H4 receptor Hs Antagonist Antagonist 7.5 pKd - 3
pKd 7.5 [3]