Synonyms: BAY 1101042 | BAY-1101042 | BAY1101042 | compound 45 [PMID: 33872507]
Compound class:
Synthetic organic
Comment: Runcaciguat (BAY 1101042) is an oral, selective soluble guanylyl cyclase (sGC) activator [1]. It is suitable for once-daily dosing.
|
|
Bioactivity Comments |
The potency of runcaciguat was determined as the MEC (minimal effective concentration) that promotes cGMP formation (determined as an at least threefold increase in basal luminescence) in a recombinant sGC-overexpressing cell line [1]. In this assay system runcaciguat's MEC was 1.8 nM. In a biochemical assay using purified enzyme its EC50 is 18 nM. |
Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|