Synonyms: compound 9 [PMID: 36044257] | GSK'254 | GSK-3640254 | GSK3640254
Compound class:
Synthetic organic
Comment: Fipravirimat (GSK3640254) is an investigational HIV-1 maturation inhibitor (MI) [1]. MIs disrupt the processing of the HIV Gag polyprotein, and this action interferes with the formation of mature, infectious virus particles. Fipravirimat retains activity against HIV-1 with known resistance mutations.
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Bioactivity Comments |
In vitro, fipravirimat (GSK3640254) inhibits replication of WT HIV-1, and HIV-1V362I/V370A with an EC50 of 3 nM [1]. |