Synonyms: AZD-3229
Compound class:
Synthetic organic
Comment: AZD3229 is a lead dual KIT/PDGFRα inhibitor [1]. It was designed for potential to treat gastrointestinal stromal tumours driven by mutations in KIT or platelet-derived growth factor α (PDGFRα).
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Bioactivity Comments |
In a biochemical kinome screening assay AZD3229 completely inhibits PDGFRα activity [1]. CSF1R, PDGFRβ, MUSK, LYN and Aurora kinase B are all inhibited by >90% in the same assay. |