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Synonyms: ARC-1905 | ARC1905 | Izervay® | Zimura
avacincaptad pegol is an approved drug (FDA (2023))
Compound class:
Nucleic acid
Comment: Avacincaptad pegol (ARC-1905) is a pegylated RNA aptamer that selectively binds to complement C5 and prevents its cleavage into C5a and C5b. This action inhibits activation of inflammasomes and the formation of membrane attack complexes (MAC).
In the sequence presented 'dfl' represents 2'-deoxy-2'-fluoro-modified bases and 'm' represents 2'-O-methyl modifications. The PEG is added at the 3' 'R'. |
