avacincaptad pegol   Click here for help

GtoPdb Ligand ID: 12857

Synonyms: ARC-1905 | ARC1905 | Izervay® | Zimura
Approved drug
avacincaptad pegol is an approved drug (FDA (2023))
Compound class: Synthetic organic
Comment: Avacincaptad pegol (ARC-1905) is a pegylated RNA aptamer that selectively binds to complement C5 and prevents its cleavage into C5a and C5b. This action inhibits activation of inflammasomes and the formation of membrane attack complexes (MAC). It is a clinical lead for age-related macular degeneration.
1. Jaffe GJ, Westby K, Csaky KG, Monés J, Pearlman JA, Patel SS, Joondeph BC, Randolph J, Masonson H, Rezaei KA. (2021)
C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial.
Ophthalmology, 128 (4): 576-586. [PMID:32882310]