thrombospondin 1   Click here for help

GtoPdb Ligand ID: 13047

Synonyms: THBS-1 | TSP-1 | TSP1
Immunopharmacology Ligand
Comment: Thrombospondin 1 is glycoprotein that is involved in cell-to-cell and cell-to-matrix interactions. It is a ligand for cell surface receptors including CD47 [2-3], CD36 [1,4-5] and SIRPα [6]. Thrombospondin 1's receptor interactions are invloved in multiple biological processes, including inflammation, angiogenesis, wound healing, apoptosis, stem cell self-renewal, cardiovascular, metabolic and immune homeostasis, and resolution of inflammation.
Species: Human
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
SIRPA (CD172a) Ligand is endogenous in the given species Hs None Binding - - -
CD47 Ligand is endogenous in the given species Hs None Binding - - - 2
[2]
CD36 molecule (CD36 blood group) Ligand is endogenous in the given species Hs None Binding - - -