thrombospondin 1

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Ligands
thrombospondin 1 (Human)

GtoPdb Ligand ID: 13047

Synonyms: THBS-1 | TSP-1 | TSP1

Compound class: Endogenous peptide in human, mouse or rat

Comment: Thrombospondin 1 is glycoprotein that is involved in cell-to-cell and cell-to-matrix interactions. It is a ligand for cell surface receptors including CD47 [2-3], CD36 [1,4-5] and SIRPα [6]. Thrombospondin 1's receptor interactions are invloved in multiple biological processes, including inflammation, angiogenesis, wound healing, apoptosis, stem cell self-renewal, cardiovascular, metabolic and immune homeostasis, and resolution of inflammation.

Species: Human

References
1. Asch AS, Silbiger S, Heimer E, Nachman RL. (1992) Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. Biochem Biophys Res Commun, 182 (3): 1208-17. [PMID:1371676]
2. Gao AG, Lindberg FP, Finn MB, Blystone SD, Brown EJ, Frazier WA. (1996) Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem, 271 (1): 21-4. [PMID:8550562]
3. Isenberg JS, Annis DS, Pendrak ML, Ptaszynska M, Frazier WA, Mosher DF, Roberts DD. (2009) Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. J Biol Chem, 284 (2): 1116-25. [PMID:19004835]
4. Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. (2000) Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med, 6 (1): 41-8. [PMID:10613822]
5. Simantov R, Febbraio M, Crombie R, Asch AS, Nachman RL, Silverstein RL. (2001) Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. J Clin Invest, 107 (1): 45-52. [PMID:11134179]
6. Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ et al.. (2014) Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury. J Am Soc Nephrol, 25 (6): 1171-86. [PMID:24511121]
7. Ye QD, Jiang H, Liao XL, Chen K, Li SS. (2017) Identification and Validation of Gene Expression Pattern and Signature in Patients with Immune Thrombocytopenia. SLAS Discov, 22 (2): 187-195. [PMID:27554456]

References

1. Asch AS, Silbiger S, Heimer E, Nachman RL. (1992)
Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding.
Biochem Biophys Res Commun, 182 (3): 1208-17. [PMID:1371676]

2. Gao AG, Lindberg FP, Finn MB, Blystone SD, Brown EJ, Frazier WA. (1996)
Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.
J Biol Chem, 271 (1): 21-4. [PMID:8550562]

3. Isenberg JS, Annis DS, Pendrak ML, Ptaszynska M, Frazier WA, Mosher DF, Roberts DD. (2009)
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.
J Biol Chem, 284 (2): 1116-25. [PMID:19004835]

4. Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. (2000)
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1.
Nat Med, 6 (1): 41-8. [PMID:10613822]

5. Simantov R, Febbraio M, Crombie R, Asch AS, Nachman RL, Silverstein RL. (2001)
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.
J Clin Invest, 107 (1): 45-52. [PMID:11134179]

6. Yao M, Rogers NM, Csányi G, Rodriguez AI, Ross MA, St Croix C, Knupp H, Novelli EM, Thomson AW, Pagano PJ et al.. (2014)
Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.
J Am Soc Nephrol, 25 (6): 1171-86. [PMID:24511121]

7. Ye QD, Jiang H, Liao XL, Chen K, Li SS. (2017)
Identification and Validation of Gene Expression Pattern and Signature in Patients with Immune Thrombocytopenia.
SLAS Discov, 22 (2): 187-195. [PMID:27554456]