Synonyms: Q-35 | Q-Roxin®
balofloxacin is an approved drug (Korean FDA (2001))
Compound class:
Synthetic organic
Comment: Balofloxacin is a fluoroquinolone antibacterial compound, with broad-spectrum activity against both Gram-positive and Gram-negative bacteria [2-3].
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Bioactivity Comments |
Balofloxacin has in vitro antibacterial activity against both Gram-negative and Gram-positive clinical isolates, including methicillin-resistant Staphylococcus aureus (MRSA; MIC90 = 6.25 μg/ml) [2]. Balofloxacin inhibits the supercoiling activity of Escherichia coli DNA gyrase, with an IC50 of 0.47 μg/ml in vitro [2]. |