Synonyms: QPX7728
Compound class:
Synthetic organic
Comment: Xeruborbactam is a bicyclic boronate β-lactamase inhibitor (BLI) with a broad-spectrum of activity against both serine and metallo-β-lactamases [1]. Xeruborbactam is under clinical evaluation and was developed as a continuation of the program that discovered vaborbactam, with the aim of expanding the spectrum of activity to allow treatment of infections caused by a wider range of pathogens.
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Bioactivity Comments |
Xeruborbactam displays potent activity against both serine and metallo-β-lactamase enzymes, including the clinically important class B enzyme NDM-1 of Enterobacteriaceae and the class D (OXA) enzymes of Acinetobacter baumannii [1-3]. When used at higher concentrations than those required for β-lactamase inhibition, xeruborbactam has direct antibacterial activity against some Gram-negative spp. [4]. |