R3/I5   Click here for help

GtoPdb Ligand ID: 1998

Synonyms: H3 relaxin B-chain/INSL5 A-chain chimera | H3 relaxin/INSL5 chimera | H3-B/INSL5 A chimera
Comment: Synthetic peptide consisting of human relaxin-3 (B chain) and human INSL5 (A chain). For the amino acid sequences of the subunits, please see their individual ligand entries.
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
RXFP4 Hs Agonist Full agonist 8.9 pKi - 2,4
pKi 8.9 [2,4]
RXFP4 Hs Agonist Full agonist 8.9 pEC50 - 2
pEC50 8.9 [2]
RXFP4 Hs Agonist Agonist 10.5 pIC50 - 4
pIC50 10.5 [4]
RXFP3 Hs Agonist Full agonist 9.3 pIC50 - 1,3
pIC50 9.3 [1,3]