Ro 25-1553   

GtoPdb Ligand ID: 2259

Synonyms: Ac-His1[Glu8,Lys12,Nle17,Ala19,Asp25,Leu26,Lys27,28,Gly29,30,Thr31]VIP-NH2(cyclo 21-25) | Ro 251553 | Ro-251553
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
VPAC2 receptor Hs Agonist Agonist 8.3 – 8.7 pEC50 - 2-3
pEC50 8.7 (EC50 2x10-9 M) [3]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 8.3 (EC50 5x10-9 M) [2]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
PAC1 receptor Hs Agonist Agonist <6.0 pEC50 - 3
pEC50 <6.0 (EC50 >1x10-6 M) [3]
Description: stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Partial agonist <6.0 pEC50 - 2-3
pEC50 <6.0 (EC50 >1x10-6 M) [3]
Description: stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
pEC50 6.0 (EC50 1x10-6 M) [2]
Description: cyclic AMP formation in CHO cells stably expressing recombinant receptor
VPAC2 receptor Hs Agonist Agonist 7.8 – 9.5 pIC50 - 1-3
pIC50 7.8 – 9.5 (IC50 1.5x10-8 – 3x10-10 M) [1-3]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
VPAC1 receptor Hs Agonist Partial agonist <6.0 – 7.0 pIC50 - 1-3
pIC50 7.0 (IC50 1x10-7 M) [1]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
pIC50 6.1 (IC50 8x10-7 M) [2]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
pIC50 <6.0 (IC50 >1x10-6 M) [3]
Description: inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
PAC1 receptor Hs Agonist Agonist <6.0 pIC50 - 3
pIC50 <6.0 (IC50 >1x10-6 M) [3]
Description: inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor
PAC1 receptor Rn Agonist Agonist <5.0 pIC50 - 1
pIC50 <5.0 (IC50 >1x10-5 M) [1]
Description: inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor