tertiapin-Q   

GtoPdb Ligand ID: 2383

Synonyms: TPN(Q)
Comment: From the venom gland of Apis mellifera (honeybee)
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir1.1 Rn Channel blocker Antagonist 8.2 – 8.9 pKi - 1,4
pKi 8.7 [4]
Voltage: -80.0 – 80.0 mV
pKi 8.2 – 8.9 [1,4]
Voltage: Physiological
Kir3.4 Rn Channel blocker Antagonist 8.1 pKi - 3
pKi 8.1 [3]
Voltage: -80.0 – 80.0 mV
Kir3.1 Rn Channel blocker Antagonist 8.0 pEC50 - 3
pEC50 8.0 (EC50 1x10-8 M) [3]
Voltage: Physiological
Kir1.1 Hs Channel blocker Inhibition 8.9 pIC50 - 4
pIC50 8.9 [4]
Kir3.1 N/A Channel blocker Antagonist 7.9 pIC50 - 2
pIC50 7.9 Kir3.1/3.4; expression in Xenopus oocytes [2]
Kir3.4 N/A Channel blocker Antagonist 7.9 pIC50 - 2
pIC50 7.9 Kir3.1/3.4 [2]