GR 113808

Ligand id: 247

Name: GR 113808

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 89.02
Molecular weight 393.17
XLogP 2.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT4 receptor Hs Antagonist Antagonist 9.3 – 10.3 pKi - 1-3,5,7-9
pKi 9.3 – 10.3 (Ki 5.1x10-10 – 5x10-11 M) [1-3,5,7-9]
5-HT4 receptor Mm Antagonist Antagonist 9.7 pKi - 6
pKi 9.7 [6]
5-HT4 receptor Rn Antagonist Antagonist 8.4 – 8.7 pKi - 4
pKi 8.4 – 8.7 [4]