Ligand id: 2688

Name: L-783483

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 97.86
Molecular weight 487.08
XLogP 7.05
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at nuclear hormone receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Peroxisome proliferator-activated receptor-β/δ Hs Agonist Full agonist 9.0 pKd - 1
pKd 9.0 [1]
Liver X receptor-β Hs Agonist Agonist 8.2 pKd - 2
pKd 8.2 [2]
Liver X receptor-α Hs Agonist Agonist 7.9 pKd - 2
pKd 7.9 [2]
Peroxisome proliferator-activated receptor-γ Hs Agonist Full agonist 7.8 pKi - 1
pKi 7.8 [1]