Synonyms: Aquest® | Kestrone® | oestrone
estrone is an approved drug
Compound class:
Metabolite
Comment: Estrone, is an important endogenous mammalian estrogen, produced in vivo from androstenedione in the ovaries, placenta, and in adipose tissue. Post-menopausally, this is the primary circulating estrogen.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Natural/Endogenous Targets | |||
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Selectivity at nuclear hormone receptors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
CYP19A1 | Converts androstenedione and testosterone to estrone and 17β-estradiol, respectively. |
Ligand mentioned in the following text fields |
3C. 3-Ketosteroid receptors overview |
Steroid hormone receptors overview |