Synonyms: leukotriene C4
Compound class:
Metabolite
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Natural/Endogenous Targets | ||||
|
Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||||||
|
Transporters Moving this Compound Across a Lipid Membrane | ||||||||
|
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Potency order of endogenous ligands at CysLT1 receptor | LTD4 > LTC4 > LTE4 | 12,14 |
Potency order of endogenous ligands at CysLT2 receptor | LTC4 ≥ LTD4 >> LTE4 | 9,13,17 |
Potency order of endogenous and other ligands at FPR2 | LXA4 = aspirin triggered lipoxin A4 = ATLa2 = resolvin D1 > LTC4 = LTD4 >> 15-deoxy-LXA4 >> fMet-Leu-Phe | 5-8,16 |
Targets where the ligand is described in the comment field | |
Target | Comment |
ABCC1 | Exhibits a broad substrate specificity [1], including LTC4 (Km 97 nM [11]) and estradiol-17β-glucuronide [15]. |
Ligand mentioned in the following text fields |
Leukotriene and lipoxin metabolism overview |
Leukotriene receptors overview |