beta-defensin 4A   Click here for help

GtoPdb Ligand ID: 3648

Synonyms: beta-defensin 2 | HBD2 | skin-antimicrobial peptide 1 (SAP1)
Comment: Human beta-defensin 4A is an antimicrobial peptide originally identified in psoriatic skin lesions [1]. It has potent antimicrobial activity against Gram-negative bacteria and the yeast Candida albicans but not the Gram-positive Staphylococcus aureus [1].
Species: Human
Bioactivity Comments
A study using a combination of recombinant β-defensins (1:1 ratio of hBD-1 and beta-defensin 4A) found promising in vivo activity against Salmonella enterica serovar Typhimurium, the pathogen that causes Typhoid Fever [2].
Natural/Endogenous Targets
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR6 Ligand is endogenous in the given species Hs Agonist Full agonist - - - 3