INSL3 B-chain analogue   Click here for help

GtoPdb Ligand ID: 3885

Comment: The peptide sequence given here (and the associated data) is for the shortest peptide analogue in the series which retained full binding to RXFP2 [1].
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Bioactivity Comments
Del Borgo et al (2006), produced a series of sequentially N- and C-terminally shortened linear analogues of the INSL3 βchain, and these were tested for binding to the RXFP2 receptor (LRG8 in the article) [1]. Table 1 provides the peptide sequence and binding assay results for each analogue.
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
RXFP2 Hs Antagonist Antagonist 5.1 pKi - 1
pKi 5.1 (Ki 7.943x10-6 M) [1]