diphenylamine-2-carboxylic acid   Click here for help

GtoPdb Ligand ID: 4182

Abbreviated name: DPC
Synonyms: fenamic acid | N-phenylanthranilic acid | NPA
PDB Ligand
Compound class: Synthetic organic
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 213.08
XLogP 3.28
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC(=O)c1ccccc1Nc1ccccc1
Isomeric SMILES OC(=O)c1ccccc1Nc1ccccc1
InChI InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16)
InChI Key ZWJINEZUASEZBH-UHFFFAOYSA-N
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
ClC-2 Hs Channel blocker - - - -
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Maxi Cl- Hs Channel blocker - - - -
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Targets where the ligand is described in the comment field
Target Comment
ClC-5 Insensitive to the channel blockers DIDS (1 mM), diphenylamine-2-carboxylic acid (1 mM), 9-anthroic acid (2 mM), NPPB (0.5 mM) and niflumic acid (1 mM)