GV196771A

Ligand id: 4208

Name: GV196771A

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 76.23
Molecular weight 399.03
XLogP 3.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GluN1 Rn Antagonist Antagonist 8.1 – 8.4 pKi - 1
pKi 8.1 – 8.4 (Ki 8x10-9 – 4x10-9 M) [Binds to: glycine site] [1]
Description: Measuring the high affinity binding site for the compound at two different splice variants expressed in HEK293 cells.
GluN2A Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2B Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2C Hs Antagonist Antagonist - - -
[Binds to: glycine site]
GluN2D Hs Antagonist Antagonist - - -
[Binds to: glycine site]