tezampanel   Click here for help

GtoPdb Ligand ID: 4245

Synonyms: LY-293,558 | LY293558
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 103.79
Molecular weight 279.17
XLogP 2.27
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)C1NCC2C(C1)CC(CC2)CCc1nnn[nH]1
Isomeric SMILES OC(=O)[C@H]1NC[C@H]2[C@@H](C1)C[C@H](CC2)CCc1nnn[nH]1
InChI InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GluA1 Hs Antagonist Antagonist - - -
GluA2 Hs Antagonist Antagonist - - -
GluA3 Hs Antagonist Antagonist - - -
GluA4 Hs Antagonist Antagonist - - -
Ligand mentioned in the following text fields