B-R13/17K H2 relaxin   Click here for help

GtoPdb Ligand ID: 4371

Synonyms: AT-001 | B13/17K H2 relaxin
Comment: An analogue of H2 relaxin, B-R13/17K H2 relaxin is a dimer of A and B chains. The arginine residues of the B chain of H2 relaxin (amino acids 13 and 17) are substituted for lysine residues, to form the analogue, whereas the A chain has the amino acid sequence of the natural subunit. The amino acid sequence of this synthetic B chain is shown on the 'structure' tab. For the structure of the A chain, see the ligand page for human relaxin (A chain).
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Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
RXFP1 Hs Antagonist Antagonist 5.0 – 6.3 pKi - 1-2
pKi 5.0 – 6.3 [1-2]
RXFP1 Hs Antagonist Antagonist 5.7 – 6.7 pIC50 - 1-2
pIC50 5.7 – 6.7 [1-2]