B-R13/17K H2 relaxin   Click here for help

GtoPdb Ligand ID: 4371

Synonyms: AT-001 | B13/17K H2 relaxin
Comment: An analogue of H2 relaxin, B-R13/17K H2 relaxin is a dimer of A and B chains. The arginine residues of the B chain of H2 relaxin (amino acids 13 and 17) are substituted for lysine residues, to form the analogue, whereas the A chain has the amino acid sequence of the natural subunit. The amino acid sequence of this synthetic B chain is shown on the 'structure' tab. For the structure of the A chain, see the ligand page for human relaxin (A chain).
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1. Hossain MA, Samuel CS, Binder C, Hewitson TD, Tregear GW, Wade JD, Bathgate RA. (2010)
The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist.
Amino Acids, 39 (2): 409-16. [PMID:20043231]
2. Neschadim A, Pritzker LB, Pritzker KP, Branch DR, Summerlee AJ, Trachtenberg J, Silvertown JD. (2014)
Relaxin receptor antagonist AT-001 synergizes with docetaxel in androgen-independent prostate xenografts.
Endocr Relat Cancer, 21 (3): 459-71. [PMID:24812057]