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Synonyms: 5-formyltetrahydrofolic acid | leucovorin | Wellcovorin®
folinic acid is an approved drug (FDA (1952))
Compound class: Synthetic organic
Comment: Folinic acid is the biologically active form of folic acid (also known as the (-)-l-isomer, citrovorum factor or (-)-folinic acid). The approved drug is called leucovorin.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Dihydrofolate reductase is the first enzyme with which folinic acid interacts, and by which it is reduced to the active metabolites tetrahydrofolic acid and methyltetrahydrofolate.
|Transporters Moving this Compound Across a Lipid Membrane