IL-23   Click here for help

GtoPdb Ligand ID: 4978

Immunopharmacology Ligand
Comment: IL-23 is an IL-12 family cytokine. Structurally it is a heterodimer consisting of IL-12B and IL-23A subunits.
Species: Human
Bioactivity Comments
IL-23 binds a heterodimeric receptor comprising an IL-12RP1 subunit (shared with the IL-12 receptor) and a unique receptor subunit, IL-23R. Receptor engagement activates JAK2 and Tyk2 to stimulate STAT1, -3, 4 and -5 signalling [3]. IL-23 plays an important role in bridging the innate and adaptive arms of the immune response [2].
The rationale for targeting the IL-23/IL-17/T helper type 17 (Th17) cell axis in the search for novel therapeutics for treating autoimmune inflammatory diseases is reviewed by Tang et al. (2012) [4], and further analysis of the role of IL-12 family cytokines in infection, inflammation and autoimmune disease is provided in [1].
Natural/Endogenous Targets
Interleukin-23 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-23 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -