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Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-23 is an IL-12 family cytokine. Structurally it is a heterodimer consisting of IL-12B and IL-23A subunits.
1. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. (2009)
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders.
Inflamm Allergy Drug Targets, 8 (1): 40-52. [PMID:19275692]
2. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. (2004)
IL-12 and IL-23: master regulators of innate and adaptive immunity.
Immunol Rev, 202: 96-105. [PMID:15546388]
3. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F et al.. (2002)
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
J Immunol, 168 (11): 5699-708. [PMID:12023369]
4. Tang C, Chen S, Qian H, Huang W. (2012)
Interleukin-23: as a drug target for autoimmune inflammatory diseases.
Immunology, 135 (2): 112-24. [PMID:22044352]