pertuzumab   Click here for help

GtoPdb Ligand ID: 5046

Synonyms: 2C4 | Omnitarg® (obsolete trade name) | Perjeta®
Approved drug
pertuzumab is an approved drug (FDA (2012), EMA (2013))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available in its IMGT/mAB-DB record.
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Primary target of this compound Hs Antibody Inhibition >8.0 pIC50 - 5
pIC50 >8.0 (IC50 <1x10-8 M) [5]
Description: Preferred value for inhibition of heregulin β1 binding to MCF7 cells.
Ligand mentioned in the following text fields