stem cell factor   Click here for help

GtoPdb Ligand ID: 5055

Abbreviated name: SCF
Synonyms: c-Kit ligand
Immunopharmacology Ligand
Comment: SCF is the endogenous ligand for c-KIT (KIT) receptor tyrosine kinase.
Species: Human
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Natural/Endogenous Targets
Target
KIT proto-oncogene, receptor tyrosine kinase
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
KIT proto-oncogene, receptor tyrosine kinase Ligand is endogenous in the given species Hs Agonist Agonist 9.6 – 9.8 pKd - 1
pKd 9.6 – 9.8 (Kd 2.4x10-10 – 1.5x10-10 M) [1]
Description: Binding affinity of KIT receptors on cell membranes from OCIM1, MO7e and HEL cells, using 125I-SCF as radioligand.