GSK-1838705A

Ligand id: 5683

Name: GSK-1838705A

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 127.51
Molecular weight 532.23
XLogP 3.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
GSK-1838705A exhibits antitumour activity in vitro and in vivo [2].
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
ribosomal protein S6 kinase A1 Hs Inhibitor Inhibition 5.8 pIC50 - 2
pIC50 5.8 (IC50 1.6x10-6 M) [2]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Insulin-like growth factor I receptor Hs Inhibitor Inhibition 8.1 pKd - 1
pKd 8.1 (Kd 7x10-9 M) [1]
ALK receptor tyrosine kinase Hs Inhibitor Inhibition 9.3 pIC50 - 2
pIC50 9.3 (IC50 5x10-10 M) [2]
Insulin receptor Hs Inhibitor Inhibition 8.8 pIC50 - 2
pIC50 8.8 (IC50 1.6x10-9 M) [2]
Insulin-like growth factor I receptor Hs Inhibitor Inhibition 8.7 pIC50 - 2
pIC50 8.7 (IC50 2x10-9 M) [2]