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Synonyms: Akt inhibitor V | Akt/protein kinase B signaling inhibitor-2 | API-2 | NSC-154020 | tricyclic nucleoside (TCN)
Compound class: Synthetic organic
Comment: The ligand image above represents this compound as used in the screens listed, and does not specify stereochemistry. The INN-assigned compound triciribine does have defined stereocentres and is represented by CID 65399.
Triciribine is an inhibitor of Akt signalling , HIV-1/2 , DNA synthesis  and exhibits in vitro and in vivo antitumour effects .
|Triciribine inhibits phosphorylation of Akt to basal levels at 100 μM, with an IC50 of 130nM . This was measured in intact cells so does not provide details of Akt isozyme specificity. This compound inhibits phosphorylation of all three human AKT isoforms, but no inhibitory constant is provided .|