Src kinase inhibitor I

Ligand id: 6042

Name: Src kinase inhibitor I

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 65.5
Molecular weight 373.14
XLogP 4.07
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
The available data for this compound against Src was measured using the chicken enzyme isoform, which provides an IC50 value of 180nM [2].
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
receptor interacting serine/threonine kinase 2 Hs Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.6x10-8 M) [2]