Compound class:
Endogenous peptide in human, mouse or rat
Comment: This endogenous peptide is a fragment of angiotensin and can be formed from ang-(1-7) in the heart [3].
Species: Human, Mouse, Rat
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Targets where the ligand is described in the comment field | |
Target | Comment |
MRGPRD | An endogenous peptide with a high degree of sequence similarity to angiotensin-(1-7) (AGT, P01019), alamandine (AGT), was shown to promote NO release in MRGPRD-transfected cells. The binding of alamandine to MRGPRD to was shown to be blocked by D-Pro7-angiotensin-(1-7), β-alanine and PD123319 [3]. Genetic ablation of MRGPRD+ neurons of adult mice decreased behavioural sensitivity to mechanical stimuli but not to thermal stimuli [1]. See reviews [2] and [4]. |