4-APPES

Ligand id: 6258

Name: 4-APPES

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 110.97
Molecular weight 411.13
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
mGlu2 receptor Hs Allosteric modulator Positive 5.7 pEC50 - 1
pEC50 5.7 (EC50 2.26x10-6 M) [1]