Ligand id: 6331

Name: [3H]JNJ-40068782    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 49.03
Molecular weight 333.18
XLogP 4.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
mGlu2 receptor Rn Allosteric modulator Positive 8.0 pKd - 1
pKd 8.0 (Kd 1x10-8 M) [1]
mGlu2 receptor Hs Allosteric modulator Positive 7.9 pKd - 1
pKd 7.9 (Kd 1.2x10-8 M) [1]