GR 144053

Ligand id: 6587

Name: GR 144053

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 96.89
Molecular weight 345.22
XLogP -0.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
integrin αIIbβ3 Hs Inhibitor Inhibition 7.4 pIC50 - 1
pIC50 7.4 (IC50 3.7x10-8 M) [1]
Description: Inhibition of ADP (10 µM)-induced aggregation in human gel-filtered platelets.