Abbreviated name: 4-HPPA
Synonyms: 4-hydroxyphenylpyruvate
Compound class:
Metabolite or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Enzymes Catalysing Reactions with this Compound as a Substrate or Product | ||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
Tyrosine aminotransferase |
Tyrosine may also be metabolized in the liver by tyrosine transaminase to generate 4-hydroxyphenylpyruvic acid, which can be further metabolized to homogentisic acid. TAT is a homodimer, where loss-of-function mutations are associated with type II tyrosinemia. |