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Synonyms: Adcetris® | anti-CD30 ADC SGN-35 | SGN 35
brentuximab vedotin is an approved drug (FDA (2011), EMA (2012))
Compound class:
Antibody
Comment: Antibody-drug conjugate (ADC) that combines an anti-CD30 antibody and the drug monomethyl auristatin E (MMAE). The PubChem ID for the MMAE component compound is CID 11542188. The invention of this ADC is claimed in patent US7090843 [4] and the original article describing the parent antibody (C10 or AC10) is [1].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. |
| Bioactivity Comments |
| Detailed information contained in the covering patent [4] describes in vitro and in vivo activity of the invention, which supports its anti-CD30 action. However, no affinity data is provided for the interaction between the antibody and its molecular target. |
| Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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