eculizumab

Ligand id: 6884

Name: eculizumab

Bioactivity Comments
Eculizumab binds to and blocks the cleavage of the complement protein C5, thereby preventing the formation of C5a. The terminal half-life of eculizumab is 11.3 ± 3.4 days [4].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C5 Hs Antibody Binding 9.2 – 10.5 pKd - 1,5
pKd 10.5 (Kd 3x10-11 M) [5]
Description: At pH7.4 in a SPR assay.
pKd 10.5 (Kd 3x10-11 M) [1]
pKd 9.2 (Kd 6x10-10 M) [5]
Description: At pH6.0 in a SPR assay.