denosumab   Click here for help

GtoPdb Ligand ID: 6886

Synonyms: AMG-162 | M05BX04 | Prolia® | Xgeva®
Approved drug
denosumab is an approved drug (FDA and EMA (2010))
Compound class: Antibody
Comment: Denosumab suppresses the activity of RANK ligand (RANKL), which normally promotes bone removal and resorption, but which becomes over active in many bone loss diseases.
Denosumab is produced from CHO cells stably expressing recombinant antibody component proteins [1].
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Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
RANK ligand Primary target of this compound Hs Antibody Binding >9.6 pIC50 - 1
pIC50 >9.6 (IC50 <2.3x10-10 M) [1]