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Synonyms: R-1450 | RG-1450 | Ro-4909832
Compound class:
Antibody
Comment: Gantenerumab targets aggregated forms of human amyloid β (Aβ) proteins Aβ42 and Aβ40. This is in contrast to solanezumab which targets soluble Aβ.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Protein sequence analysis reveals that gantenerumab is likely to be clone #7.9.H7 in patent US7794719 [1]. |
| Bioactivity Comments |
| In vitro gantenerumab is able to effect clearance of Aβ from post-mortem human Alzheimer's diseased brain slices, and binds to Aβ plaques in the brains of AD model mice following systemic delivery [2]. |
| Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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