pargyline   

GtoPdb Ligand ID: 7262

Synonyms: A-19120 | Eutonyl® | MO-911
pargyline is an approved drug
Compound class: Synthetic organic
Comment: Pargyline is a monoamine oxidase inhibitor (MAOI).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 3.24
Molecular weight 159.1
XLogP 2.04
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CN(Cc1ccccc1)CC#C
Isomeric SMILES CN(Cc1ccccc1)CC#C
InChI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3
InChI Key DPWPWRLQFGFJFI-UHFFFAOYSA-N
Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed molecular target(s) to substantiate its MMOA, and have therefore not tagged a primary drug target.
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Monoamine oxidase B Rn Inhibitor Inhibition 5.7 pIC50 - 1
pIC50 5.7 (IC50 1.8x10-6 M) [1]