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Synonyms: XOMA 052 | XOMA-052
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
|The inhibitory effects gevokizumab of arise from a classic allosteric ternary complex mechanism whereby the antibody binds to the orthosteric agonist IL-1β, modulating the interaction with the orthosteric site on the receptor [3,6].
Sequence analysis of the peptide sequence of gevokizumab indicate a match for sequence ID 15 from patent US7531166 , suggesting that gevokizumab derives from clone AB7. Data for clone AB7 is included in the interaction table below.
|Selectivity at ligand targets|
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